The mechanism of squalene oxidation lies in that its low ionization threshold period can donate or receive electrons without damaging the molecular structure of cells, and squalene can terminate the chain reaction of hydroperoxides in the lipid peroxidation pathway. Studies have shown that the peroxidation of sebum is mainly caused by singlet oxygen, and the singlet oxygen quenching rate constant of squalene in human sebum is much larger than that of other lipids in human skin. extinction constant. However, it should be noted that although squalene can block lipid peroxidation, the products of squalene, such as unsaturated fatty acids, also have an irritating effect on the skin.
Squalene peroxide may play a major role in the pathogenesis of acne. In animal experimental models, it has been established that squalene monoperoxide is highly comedogenic, and the content of squalene peroxide gradually increases under UV irradiation. Therefore, it is suggested that acne patients should pay attention to sun protection, and sunscreens can avoid squalene peroxidation at physiological concentrations caused by ultraviolet rays.
Skin analyzer can be used to detect the effect of sun cream. The the UV image is shown dark blue if chemical sunscreen is applied; if physical sunscreen is applied, the image is reflective, similar to fluorescent residue.
Post time: Apr-29-2022
